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Review
. 2002 Dec;9(12):1268-70.
doi: 10.1016/s1074-5521(02)00289-2.

Combinatorial glycosylation of glycopeptide antibiotics

Richard H Baltz  1
Affiliations
Review

Combinatorial glycosylation of glycopeptide antibiotics

Richard H Baltz. Chem Biol. 2002 Dec.

Abstract

The glycosyltransferases GtfE and GtfD from the vancomycin producer Amycolatopsis orientalis have promiscuous substrate and NDP-sugar specificities. They have been used to generate novel glycopeptide antibiotics containing the heptapeptide scaffolds of vancomycin and teichoplanin.

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