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Clinical Trial
. 2003 Jan;47(1):371-4.
doi: 10.1128/AAC.47.1.371-374.2003.

Penetration of fosfomycin into inflammatory lesions in patients with cellulitis or diabetic foot syndrome

F J Legat  1 , A Maier, P Dittrich, P Zenahlik, T Kern, S Nuhsbaumer, M Frossard, W Salmhofer, H Kerl, M Müller
Affiliations
Clinical Trial

Penetration of fosfomycin into inflammatory lesions in patients with cellulitis or diabetic foot syndrome

F J Legat et al. Antimicrob Agents Chemother. 2003 Jan.

Abstract

We investigated the distribution of the broad-spectrum antibiotic fosfomycin in infected soft tissue of patients with uncomplicated cellulitis of the lower extremities or diabetic foot infection using in vivo microdialysis. Our findings suggest that fosfomycin exhibits good and similar penetration into the fluid in the interstitial space in inflamed and noninflamed soft tissue in patients.

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Figures

FIG. 1.
FIG. 1.
Profiles of time versus fosfomycin concentration in plasma and fluid in interstitial space in noninflamed and inflamed subcutaneous soft tissue in patients with cellulitis (a) or diabetic foot infection (b). Patients with severe uncomplicated cellulitis of lower extremities were given 68 ± 4.9 mg of fosfomycin per kg of body weight, and patients with diabetic foot infection were given 67.8 ± 4.9 mg/kg of body weight. Fosfomycin was infused i.v. for 30 min starting at time zero (t = 0 min). Results are given as means ± SEMs (six patients in each group).
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