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. 2003 Jan;47(1):398-9.
doi: 10.1128/AAC.47.1.398-399.2003.

Comparison of linezolid activities under aerobic and anaerobic conditions against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium

Brent W Gunderson  1 , Khalid H Ibrahim, Charles A Peloquin, Laurie B Hovde, John C Rotschafer
Affiliations

Comparison of linezolid activities under aerobic and anaerobic conditions against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium

Brent W Gunderson et al. Antimicrob Agents Chemother. 2003 Jan.

Abstract

Methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium were exposed to linezolid (MIC of 2 mg/liter) under aerobic or anaerobic conditions in an in vitro pharmacodynamic model. Drug concentration and half-life were adjusted to simulate clinical dosing (600 mg twice daily) of linezolid. Linezolid produced a 2-log(10) killing at 24 h, and rates of killing against each of these facultative organisms as measured by mean survival time appeared similar under aerobic and anaerobic conditions.

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Figures

FIG. 1.
FIG. 1.
Activities of linezolid against MRSA (A) and VREF (B) under aerobic (circles) and anaerobic (squares) conditions along with growth control (triangles).
See this image and copyright information in PMC

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