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. 2003 Jan;47(1):436-9.
doi: 10.1128/AAC.47.1.436-439.2003.

Molecular characterization of quinolone-resistant Neisseria gonorrhoeae in Hong Kong

Kai Man Kam  1 , Shirley Sin Yee Kam, Danny Tze Leung Cheung, Viola Wai Na Tung, Wai Fun Au, May May Cheung
Affiliations

Molecular characterization of quinolone-resistant Neisseria gonorrhoeae in Hong Kong

Kai Man Kam et al. Antimicrob Agents Chemother. 2003 Jan.

Abstract

In Hong Kong, ParC changes among high-level quinolone-resistant Neisseria gonorrhoeae (QRNG) isolates at Ser-87-->Arg were associated with a higher level of resistance than a Ser-87-->Ile alteration. Two previously undescribed mutations in clinical isolates occurring in gyrA, conferring Ala-92-->Pro and Asp-95-->Tyr changes, were detected. Nine different outer membrane lipoprotein (Lip) repeat classes-11 to 19 repeats-were identified, with repeat lengths of 16 and 17 the most common, indicating considerable strain diversity.

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References

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