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. 2002 Dec;65(12):1793-7.
doi: 10.1021/np020173x.

Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens

George R Pettit  1 , John C Knight, Delbert L Herald, Richard Davenport, Robin K Pettit, Bruce E Tucker, Jean M Schmidt
Affiliations

Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens

George R Pettit et al. J Nat Prod. 2002 Dec.

Abstract

Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI(50) microg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).

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