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. 2002 Dec 26:2:37.
doi: 10.1186/1471-2407-2-37. Epub 2002 Dec 26.

Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000

Kenji Shibuya  1 , Colin D Mathers, Cynthia Boschi-Pinto, Alan D Lopez, Christopher J L Murray
Affiliations

Global and regional estimates of cancer mortality and incidence by site: II. Results for the global burden of disease 2000

Kenji Shibuya et al. BMC Cancer. .

Abstract

Background: Mortality estimates alone are not sufficient to understand the true magnitude of cancer burden. We present the detailed estimates of mortality and incidence by site as the basis for the future estimation of cancer burden for the Global Burden of Disease 2000 study.

Methods: Age- and sex- specific mortality envelope for all malignancies by region was derived from the analysis of country life-tables and cause of death. We estimated the site-specific cancer mortality distributions from vital records and cancer survival model. The regional cancer mortality by site is estimated by disaggregating the regional cancer mortality envelope based on the mortality distribution. Estimated incidence-to-mortality rate ratios were used to back calculate the final cancer incidence estimates by site.

Results: In 2000, cancer accounted for over 7 million deaths (13% of total mortality) and there were more than 10 million new cancer cases world wide in 2000. More than 60% of cancer deaths and approximately half of new cases occurred in developing regions. Lung cancer was the most common cancers in the world, followed by cancers of stomach, liver, colon and rectum, and breast. There was a significant variations in the distribution of site-specific cancer mortality and incidence by region.

Conclusions: Despite a regional variation, the most common cancers are potentially preventable. Cancer burden estimation by taking into account both mortality and morbidity is an essential step to set research priorities and policy formulation. Also it can used for setting priorities when combined with data on costs of interventions against cancers.

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Figures

Figure 1
Figure 1
Approaches to estimating global and regional cancer mortality and incidence by site for the Global Burden of Disease 2000 (GBD 2000)
Figure 2
Figure 2
Regional distribution of mortality by cause, 2000
Figure 3
Figure 3
Age-standardised mortality rate from all cancers by region, 2000
Figure 4
Figure 4
Age-standardised incidence rate from all cancers by region, 2000
See this image and copyright information in PMC

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