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Review
. 2002 Nov:976:300-14.
doi: 10.1111/j.1749-6632.2002.tb04753.x.

Potassium-dependent sodium-calcium exchange through the eye of the fly

R Webel  1 , K Haug-Collet, B Pearson, R T Szerencsei, R J Winkfein, P P M Schnetkamp, N J Colley
Affiliations
Review

Potassium-dependent sodium-calcium exchange through the eye of the fly

R Webel et al. Ann N Y Acad Sci. 2002 Nov.

Abstract

In this review, we describe the characterization of a Drosophila sodium/calcium-potassium exchanger, Nckx30C. Sodium/calcium (-potassium) exchangers (NCX and NCKX) are required for the rapid removal of calcium in excitable cells. The deduced protein topology for NCKX30C is similar to that of mammalian NCKX, with 5 hydrophobic domains in the amino terminus separated from 6 at the carboxy-terminal end by a large intracellular loop. NCKX30C functions as a potassium-dependent sodium-calcium exchanger and is expressed in adult neurons and during ventral nerve cord development in the embryo. Nckx30C is expressed in a dorsal/ventral pattern in the eye-antennal disc, suggesting that large fluxes of calcium may be occurring during imaginal disc development in the larvae. NCKX30C may play a critical role in modulating calcium during development as well as in the removal of calcium and maintenance of calcium homeostasis in adults.

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