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Clinical Trial
. 2002 Dec;19(12):550-4.
doi: 10.1023/a:1021207014429.

Human chorionic gonadotropin combined with progesterone for luteal support improves pregnancy rate in patients with low late-midluteal estradiol levels in IVF cycles

Akihisa Fujimoto  1 , Yutaka Osuga, Toshihiro Fujiwara, Tetsu Yano, Osamu Tsutsumi, Mikio Momoeda, Koji Kugu, Kaori Koga, Yutaka Morita, Osamu Wada, Yuji Taketani
Affiliations
Clinical Trial

Human chorionic gonadotropin combined with progesterone for luteal support improves pregnancy rate in patients with low late-midluteal estradiol levels in IVF cycles

Akihisa Fujimoto et al. J Assist Reprod Genet. 2002 Dec.

Abstract

Purpose: To investigate how late-midluteal estradiol levels relate to the pregnancy outcome in IVF cycles, and to assess whether human chorionic gonadotropin (hCG) for luteal support benefits the pregnancy outcome of patients with low late-midluteal estradiol levels.

Methods: The pregnancy rate of 436 women undergoing first IVF cycles with long protocol and luteal support with progesterone alone were analyzed. Unsuccessful women with low late-midluteal estradiol levels (< 100 pg/mL) proceeded with the exploratory second IVF cycles where they were randomly given with either progesterone alone (P protocol) or hCG +progesterone (P+hCG protocol) for luteal support.

Results: Pregnancy rate in women with low late-midluteal estradiol levels was significantly lower compared to that with medium (100-500 pg/mL) and high (> 500 pg/mL) levels (13.3, 26.8, and 36.3%, respectively). P+hCG protocol increased late-midluteal estradiol levels and produced a significantly higher pregnancy rate (31.7%) than P protocol (13.7%).

Conclusions: hCG in combination with progesterone for luteal support was suggested to benefit women undergoing IVF with low late-midluteal estradiol levels.

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References

    1. Younis JS, Simon A, Laufer N. Endometrial preparation: lessons from oocyte donation. Fertil Steril. 1996;66:873–884. - PubMed
    1. de Ziegler D, Bergeron C, Cornel C, Medalie DA, Massai MR, Milgrom E, Frydman R, Bouchard P. Effects of luteal estradiol on the secretory transformation of human endometrium and plasma gonadotropins. J Clin Endocrinol Metab. 1992;74:322–331. - PubMed
    1. Younis JS, Ezra Y, Sherman Y, Simon A, Schenker JG, Laufer N. The effect of estradiol depletion during the luteal phase on endometrial development. Fertil Steril. 1994;62:103–107. - PubMed
    1. Muasher S, Acosta AA, Garcia JE, Jones GS, Jones HW., Jr Luteal phase serum estradiol and progesterone in in vitro fertilization. Fertil Steril. 1984;41:838–843. - PubMed
    1. Nylund L, Beskow C, Carlstrom K, Fredricsson B, Gustafson O, Lunell NO, Pousette A, Rosenborg L, Slotte H, Akerlof E. The early luteal phase in successful and unsuccessful implantation after IVF-ET. Hum Reprod. 1990;5:40–42. - PubMed