Comment
doi: 10.1016/s1097-2765(02)00789-x.
BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer?
Affiliations
- PMID: 12504001
- DOI: 10.1016/s1097-2765(02)00789-x
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Comment
BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer?
Mol Cell.
2002 Dec.
Free article
Abstract
The mechanistic link between the BRCA2 protein, homologous recombination, and genomic instability has become clearer as a result of recent work describing the structures of different BRCA2 domains bound to Rad51 and to single-stranded DNA.
Comment on
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BRCA2 is required for homology-directed repair of chromosomal breaks.Mol Cell. 2001 Feb;7(2):263-72. doi: 10.1016/s1097-2765(01)00174-5. Mol Cell. 2001. PMID: 11239455
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Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.Mol Cell. 2001 Feb;7(2):273-82. doi: 10.1016/s1097-2765(01)00175-7. Mol Cell. 2001. PMID: 11239456
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