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. 2003 Jan 5;458(3):327-8.
doi: 10.1016/s0014-2999(02)02785-1.

Beneficial effect of pharmacological mobilization of bone marrow in experimental cerebral ischemia

Isabelle Six  1 , Gaëlle Gasan, Emmanuelle Mura, Régis Bordet
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Beneficial effect of pharmacological mobilization of bone marrow in experimental cerebral ischemia

Isabelle Six et al. Eur J Pharmacol. .

Abstract

Bone marrow stem cells are able to differentiate into nervous and endothelial cells. In our study, we found that administration of a bone marrow-stimulating factor (granulocyte colony-stimulating factor; G-CSF 50 microg/kg) decrease the brain infarct volume and enhance survival rate in a model of cerebral ischemia. Taken together, these data suggest a beneficial effect of a pharmacological endogenous bone marrow mobilization in the course of cerebral ischemia and open a new direction for cellular therapy strategy in stroke.

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