Review
doi: 10.1016/s1286-4579(02)00036-9.
Regulatory pathways involved in the infection-induced production of IFN-gamma by NK cells
Affiliations
- PMID: 12505525
- DOI: 10.1016/s1286-4579(02)00036-9
Item in Clipboard
Review
Regulatory pathways involved in the infection-induced production of IFN-gamma by NK cells
Microbes Infect.
2002 Dec.
Free article
Abstract
The production of interferon gamma (IFN-gamma) by natural killer (NK) cells provides an innate mechanism of resistance to many intracellular pathogens. These events are regulated by multiple cytokines and transcription factors which have both positive and negative effects. This article reviews the role of cytokines, as well as costimulatory and signaling pathways, involved in NK cell responses associated with resistance to infection.
Similar articles
-
TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production.J Immunol. 2005 Aug 1;175(3):1636-42. doi: 10.4049/jimmunol.175.3.1636. J Immunol. 2005. PMID: 16034103
-
The regulation and activation of CD44 by natural killer (NK) cells and its role in the production of IFN-gamma.J Interferon Cytokine Res. 2004 May;24(5):301-9. doi: 10.1089/107999004323065093. J Interferon Cytokine Res. 2004. PMID: 15153314
-
Src homology 2-containing inositol 5'-phosphatase 1 negatively regulates IFN-gamma production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12.Cancer Res. 2005 Oct 1;65(19):9099-107. doi: 10.1158/0008-5472.CAN-04-4424. Cancer Res. 2005. PMID: 16204085
-
Regulation of interferon-gamma during innate and adaptive immune responses.Adv Immunol. 2007;96:41-101. doi: 10.1016/S0065-2776(07)96002-2. Adv Immunol. 2007. PMID: 17981204 Review.
-
Metabolic Regulation of Natural Killer Cell IFN-γ Production.Crit Rev Immunol. 2016;36(2):131-147. doi: 10.1615/CritRevImmunol.2016017387. Crit Rev Immunol. 2016. PMID: 27910764 Free PMC article. Review.
Cited by
-
LNFPIII/LeX-stimulated macrophages activate natural killer cells via CD40-CD40L interaction.Clin Diagn Lab Immunol. 2005 Sep;12(9):1041-9. doi: 10.1128/CDLI.12.9.1041-1049.2005. Clin Diagn Lab Immunol. 2005. PMID: 16148169 Free PMC article.
-
Deviation from a strong Th1-dominated to a modest Th17-dominated CD4 T cell response in the absence of IL-12p40 and type I IFNs sustains protective CD8 T cells.J Immunol. 2008 Mar 15;180(6):4109-15. doi: 10.4049/jimmunol.180.6.4109. J Immunol. 2008. PMID: 18322221 Free PMC article.
-
Role of natural killer cells in innate protection against lethal ebola virus infection.J Exp Med. 2004 Jul 19;200(2):169-79. doi: 10.1084/jem.20032141. Epub 2004 Jul 12. J Exp Med. 2004. PMID: 15249592 Free PMC article.
-
Early IFN-gamma production after YF 17D vaccine virus immunization in mice and its association with adaptive immune responses.PLoS One. 2013 Dec 6;8(12):e81953. doi: 10.1371/journal.pone.0081953. eCollection 2013. PLoS One. 2013. PMID: 24324734 Free PMC article.
-
Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update.Bosn J Basic Med Sci. 2018 Nov 5;18(4):297-304. doi: 10.17305/bjbms.2018.3539. Bosn J Basic Med Sci. 2018. PMID: 30179586 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
