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. 2003 Jan 17;960(1-2):259-62.
doi: 10.1016/s0006-8993(02)03542-4.

Loss of muscarinic M4 receptors in hippocampus of Alzheimer patients

Ezra Mulugeta  1 , Evert Karlsson, Atiqul Islam, Raj Kalaria, Halinder Mangat, Bengt Winblad, Abdu Adem
Affiliations

Loss of muscarinic M4 receptors in hippocampus of Alzheimer patients

Ezra Mulugeta et al. Brain Res. .

Abstract

We assessed muscarinic M(1), M(2) and M(4) receptor subtypes in the hippocampus of Alzheimer's and control brains by receptor autoradiography using ligands such as [(125)I]muscarinic toxin-1 ([(125)I]MT-1, M(1) selective), [(3)H]AFDX-384 (M(2) partially selective) and [(125)I]muscarinic toxin 4 ([(125)I]M(4) toxin-1, M(4) selective). Our results revealed a significant decrease in muscarinic M(4) receptor binding in the dentate gyrus and CA4 regions of brain sections from Alzheimer's patients compared to controls. No changes in the density of M(1) or M(2) receptor binding were observed. Our findings suggest that, relative to other muscarinic receptor subtypes, the M(4) receptor could be the subtype which is selectively compromised in Alzeheimer's disease (AD).

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