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Comparative Study
. 2002 Dec;97(6):1271-5.
doi: 10.3171/jns.2002.97.6.1271.

Downregulation of cerebrospinal fluid production in patients with chronic hydrocephalus

Gerald D Silverberg  1 , Stephen Huhn, Richard A Jaffe, Steven D Chang, Thomas Saul, Gary Heit, Ann Von Essen, Edward Rubenstein
Affiliations
Comparative Study

Downregulation of cerebrospinal fluid production in patients with chronic hydrocephalus

Gerald D Silverberg et al. J Neurosurg. 2002 Dec.

Abstract

Object: The goal of this study was to determine the effect of hydrocephalus on cerebrospinal fluid (CSF) production rates in patients with acute and chronic hydrocephalus.

Methods: The authors studied CSF production both in patients presenting with acute and chronic hydrocephalus, and patients with Parkinson disease (PD) of a similar mean age, whose CSF production was known to be normal. A modification of the Masserman method was used to measure CSF production through a ventricular catheter. The CSF production rates (means +/- standard deviations) in the three groups were then compared. The patients with PD had a mean CSF production rate of 0.42 +/- 0.13 ml/minute; this value lies within the normal range measured using this technique. Patients with acute hydrocephalus had a similar CSF production rate of 0.4 +/- 0.13 ml/minute, whereas patients with chronic hydrocephalus had a significantly decreased mean CSF production rate of 0.25 +/- 0.08 ml/minute.

Conclusions: The authors postulate that chronic increased intracranial pressure causes downregulation of CSF production.

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Comment in

  • Cerebrospinal fluid production.
    Czosnyka M, Czosnyka Z, Schmidt EA, Momjian S. Czosnyka M, et al. J Neurosurg. 2003 Jul;99(1):206-7; author reply 207. doi: 10.3171/jns.2003.99.1.0206. J Neurosurg. 2003. PMID: 12854768 No abstract available.
  • Normal-pressure hydrocephalus and Alzheimer disease.
    Serot JM, Bene MC, Faure GC. Serot JM, et al. J Neurosurg. 2003 Oct;99(4):797-8; author reply 798-9. doi: 10.3171/jns.2003.99.4.0797. J Neurosurg. 2003. PMID: 14567622 No abstract available.

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