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Comparative Study
. 2002 Aug;22(4):455-62.
doi: 10.1023/a:1021067822435.

Transient forebrain ischemia increases the blood-brain barrier permeability for albumin in stroke-prone spontaneously hypertensive rats

Csongor S Abrahám  1 , Noboru Harada, Mária A Deli, Masami Niwa
Affiliations
Comparative Study

Transient forebrain ischemia increases the blood-brain barrier permeability for albumin in stroke-prone spontaneously hypertensive rats

Csongor S Abrahám et al. Cell Mol Neurobiol. 2002 Aug.

Abstract

1. The aim of the present study was to reveal the effect of transient forebrain ischemia on the regional and temporal changes in the permeability of the blood-brain barrier (BBB) permeability for sodium fluorescein (MW: 376 Da) and Evan's blue-labeled albumin (MW: 67 kDa) in stroke-prone spontaneously hypertensive rats (SHRSP). 2. BBB permeability was significantly higher in the brain regions of 16-week-old control SHRSP than those in age-matched normotensive Wistar-Kyoto rats. 3. Transient forebrain ischemia evoked by 10-min bilateral carotid occlusion increased the permeability of the BBB for albumin, but not for sodium fluorescein, after 6 and 24 h of reperfusion in brain regions of SHRSP. 4. Extravasation of serum macromolecules may contribute to neuronal loss and development of hypertensive encephalopathy in SHRSP.

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References

    1. Deli, M. A., Németh, L., Falus, A., and Ábrahám, C. S. (2000). Effect of N, N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine on the blood-brain barrier permeability in the rat. Eur. J. Pharmacol.387:63–72. - PubMed
    1. Frederiksson, K., Kalimo, H., Westergren, I., Kåhrström, J., and Johansson, B. B. (1987). Blood-brain barrier leakage and brain edema in stroke-prone spontaneously hypertensive rats. Effect of chronic sympathectomy and low protein/high salt diet. Acta Neuropathol. (Berl.)74:259–268. - PubMed
    1. Hassel, B., Iversen, E.G., and Fonnum, F. (1994). Neurotoxicity of albumin in vivo. Neurosci. Lett.167:29–32. - PubMed
    1. Ibaragi, M., and Niwa, M. (1989). Atrial natriuretic peptide and angiotensin II binding sites in cerebral capillaries of spontaneously hypertensive rats. Cell. Mol. Neurobiol.9:221–231. - PMC - PubMed
    1. Kataoka, Y., Cui, Y., Yamada, H., Utsunomiya, K., Niiya, H., Yanase, H., Nakamura, Y., Mitani, A., Kataoka, K., and Watanabe, Y. (2000). Neovascularization with blood-brain barrier breakdown in delayed neuronal death. Biochem. Biophys. Res. Commun.273:637–641. - PubMed

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