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Review
. 2003 Jan;58(1):65-8.
doi: 10.1002/ccd.10393.

Combination platelet glycoprotein IIb/IIIa receptor and lepirudin administration during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia

Duane S Pinto  1 , Robert T Sperling, Thomas M Tu, David J Cohen, Joseph P Carrozza Jr
Affiliations
Review

Combination platelet glycoprotein IIb/IIIa receptor and lepirudin administration during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia

Duane S Pinto et al. Catheter Cardiovasc Interv. 2003 Jan.

Abstract

We evaluated a combination therapy using glycoprotein IIb/IIIa receptor antagonism and direct thrombin inhibition in nine patients with heparin-induced thrombocytopenia (HIT) undergoing 10 percutaneous coronary interventions (PCIs). In selected patients with HIT, the combination of a direct thrombin inhibitor, lepirudin, and abciximab, tirofiban, or eptifibatide appears to be a safe and effective anticoagulation strategy for PCI.

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