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. 2003 Feb;36(2):205-6.
doi: 10.1002/gcc.10159.

Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)

Paola Dal Cin  1 , Bradley J Quade, David M Neskey, Michael S Kleinman, Stanislawa Weremowicz, Cynthia C Morton
Affiliations

Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)

Paola Dal Cin et al. Genes Chromosomes Cancer. 2003 Feb.

Abstract

Intravenous leiomyomatosis (IVL) is a rare smooth-muscle proliferation that is of special interest because of its quasi-malignant behavior. Our finding of a specific chromosomal aberration, a der(14)t(12;14)(q15;q24), in a second case of IVL suggests that it may be characteristic of IVL. We propose that IVL arises from a uterine leiomyoma with a t(12;14)(q15;q24). The presence of an extra copy of 12q15-qter and/or loss of 14q24-qter may be a critical genetic event(s) leading to intravascular intrusion and proliferation.

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