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. 1976 Jan;151(1):93-6.
doi: 10.3181/00379727-151-39150.

Pyrogen from mouse macrophages causes fever in mice

P Bodel, H Miller

Pyrogen from mouse macrophages causes fever in mice

P Bodel et al. Proc Soc Exp Biol Med. 1976 Jan.

Abstract

Mouse peritoneal macrophages, after phagocytosis, release an endogenous (leucocyte) pyrogen. Intravenous injection of stimulated cell culture supernatant produces a prompt, monophasic fever in mice maintained in a 35 degree environment. The pyrogen is distinct from endotoxin, and resembles cell pyrogens of other species in heat-lability and pronase sensitivity. Human leucocyte pyrogen produces identical responses in mice. Measurement of fever in mice appears to provide a sensitive biological assay for endogenous pyrogens.

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