doi: 10.3181/00379727-151-39150.
Pyrogen from mouse macrophages causes fever in mice
- PMID: 1250862
- DOI: 10.3181/00379727-151-39150
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Pyrogen from mouse macrophages causes fever in mice
Proc Soc Exp Biol Med.
1976 Jan.
Abstract
Mouse peritoneal macrophages, after phagocytosis, release an endogenous (leucocyte) pyrogen. Intravenous injection of stimulated cell culture supernatant produces a prompt, monophasic fever in mice maintained in a 35 degree environment. The pyrogen is distinct from endotoxin, and resembles cell pyrogens of other species in heat-lability and pronase sensitivity. Human leucocyte pyrogen produces identical responses in mice. Measurement of fever in mice appears to provide a sensitive biological assay for endogenous pyrogens.
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