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Review
. 2003 Jan;3(1):35-45.
doi: 10.1038/nrc971.

Targeting tumours with genetically enhanced T lymphocytes

Michel Sadelain  1 , Isabelle Rivière, Renier Brentjens
Affiliations
Review

Targeting tumours with genetically enhanced T lymphocytes

Michel Sadelain et al. Nat Rev Cancer. 2003 Jan.

Abstract

The genetic modification of T lymphocytes is an important approach to investigating normal T-cell biology and to increasing antitumour immunity. A number of genetic strategies aim to increase the recognition of tumour antigens, enhance antitumour activities and prevent T-cell malfunction. T cells can also be engineered to increase safety, as well as to express markers that can be tracked by non-invasive imaging technologies. Genetically modified T cells are therefore proving to be of great value for basic immunology and experimental immunotherapy.

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