Review
doi: 10.1038/nrc967.
Metastasis suppressors alter the signal transduction of cancer cells
Affiliations
- PMID: 12509767
- DOI: 10.1038/nrc967
Item in Clipboard
Review
Metastasis suppressors alter the signal transduction of cancer cells
Nat Rev Cancer.
2003 Jan.
Abstract
Tumour metastasis is a significant contributor to death in cancer patients. Eight metastasis-suppressor genes that reduce the metastatic propensity of a cancer cell line in vivo without affecting its tumorigenicity have been identified. These affect important signal-transduction pathways, including mitogen-activated protein kinases, RHO, RAC and G-protein-coupled and tyrosine-kinase receptors. So how might we use this knowledge to improve the treatment of patients with cancer?
Similar articles
-
Metastasis suppression: the evolving role of metastasis suppressor genes for regulating cancer cell growth at the secondary site.J Urol. 2003 Mar;169(3):1122-33. doi: 10.1097/01.ju.0000051580.89109.4b. J Urol. 2003. PMID: 12576866 Review.
-
The biology of a prostate cancer metastasis suppressor protein: Raf kinase inhibitor protein.J Cell Biochem. 2005 Feb 1;94(2):273-8. doi: 10.1002/jcb.20169. J Cell Biochem. 2005. PMID: 15565643 Review.
-
Opposing roles of netrin-1 and the dependence receptor DCC in cancer cell invasion, tumor growth and metastasis.Oncogene. 2007 Aug 16;26(38):5615-25. doi: 10.1038/sj.onc.1210347. Epub 2007 Mar 5. Oncogene. 2007. PMID: 17334389
-
G-protein-coupled receptors and tyrosine kinases: crossroads in cell signaling and regulation.Trends Endocrinol Metab. 2006 Mar;17(2):48-54. doi: 10.1016/j.tem.2006.01.006. Epub 2006 Feb 7. Trends Endocrinol Metab. 2006. PMID: 16460957 Review.
-
Regulatory processes affecting androgen receptor expression, stability, and function: potential targets to treat hormone-refractory prostate cancer.J Cell Biochem. 2006 Aug 15;98(6):1408-23. doi: 10.1002/jcb.20927. J Cell Biochem. 2006. PMID: 16619263 Review.
Cited by
-
Predictive significance of STK17A in patients with gastric cancer and association with gastric cancer cell proliferation and migration.Oncol Rep. 2021 Jun;45(6):119. doi: 10.3892/or.2021.8070. Epub 2021 May 6. Oncol Rep. 2021. PMID: 33955523 Free PMC article.
-
Innovative therapeutic strategies in the treatment of brain metastases.Int J Mol Sci. 2013 Jan 22;14(1):2135-74. doi: 10.3390/ijms14012135. Int J Mol Sci. 2013. PMID: 23340652 Free PMC article.
-
Pak1/LIMK1/Cofilin Pathway Contributes to Tumor Migration and Invasion in Human Non-Small Cell Lung Carcinomas and Cell Lines.Korean J Physiol Pharmacol. 2012 Jun;16(3):159-65. doi: 10.4196/kjpp.2012.16.3.159. Epub 2012 Jun 26. Korean J Physiol Pharmacol. 2012. PMID: 22802696 Free PMC article.
-
Metastasis suppressor proteins: discovery, molecular mechanisms, and clinical application.Clin Cancer Res. 2006 Jul 1;12(13):3882-9. doi: 10.1158/1078-0432.CCR-06-1014. Clin Cancer Res. 2006. PMID: 16818682 Free PMC article. Review.
-
MicroRNA-29a Functions as a Tumor Suppressor and Increases Cisplatin Sensitivity by Targeting NRAS in Lung Cancer.Technol Cancer Res Treat. 2018 Jan 1;17:1533033818758905. doi: 10.1177/1533033818758905. Technol Cancer Res Treat. 2018. PMID: 29495918 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
