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Clinical Trial
. 2003 Jan 4;326(7379):13.
doi: 10.1136/bmj.326.7379.13.

Analgesic effect of breast feeding in term neonates: randomised controlled trial

Ricardo Carbajal  1 , Soocramanien Veerapen, Sophie Couderc, Myriam Jugie, Yves Ville
Affiliations
Clinical Trial

Analgesic effect of breast feeding in term neonates: randomised controlled trial

Ricardo Carbajal et al. BMJ. .

Abstract

Objectives: To investigate whether breast feeding is effective for pain relief during venepuncture in term neonates and compare any effect with that of oral glucose combined with a pacifier.

Design: Randomised controlled trial.

Participants: 180 term newborn infants undergoing venepuncture; 45 in each group.

Interventions: During venepuncture infants were either breast fed (group 1), held in their mother's arms without breast feeding (group 2), given 1 ml of sterile water as placebo (group 3), or given 1 ml of 30% glucose followed by pacifier (group 4). Video recordings of the procedure were assessed by two observers blinded to the purpose of the study.

Main outcome measures: Pain related behaviours evaluated with two acute pain rating scales: the Douleur Aiguë Nouveau-né scale (range 0 to 10) and the premature infant pain profile scale (range 0 to 18).

Results: Median pain scores (interquartile range) for breast feeding, held in mother's arms, placebo, and 30% glucose plus pacifier groups were 1 (0-3), 10 (8.5-10), 10 (7.5-10), and 3 (0-5) with the Douleur Aiguë Nouveau-né scale and 4.5 (2.25-8), 13 (10.5-15), 12 (9-13), and 4 (1-6) with the premature infant pain profile scale. Analysis of variance showed significantly different median pain scores (P<0.0001) among the groups. There were significant reductions in both scores for the breast feeding and glucose plus pacifier groups compared with the other two groups (P<0.0001, two tailed Mann-Whitney U tests between groups). The difference in Douleur Aiguë Nouveau-né scores between breast feeding and glucose plus pacifier groups was not significant (P=0.16).

Conclusions: Breast feeding effectively reduces response to pain during minor invasive procedure in term neonates.

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Figures

Figure 1
Figure 1
Trial profile and participant flow. All but one randomised infant completed trial. In group 1 one infant was excluded from analysis because her face was covered by her mother's head during half the procedure
Figure 2
Figure 2
Pain during venepuncture in 179 infants according to Douleur Aiguë Nouveau-né (DAN) scale (0 to 10). Median values, interquartile ranges, and individual values
Figure 3
Figure 3
Pain during venepuncture in 179 infants according to premature infant pain profile (PIPP) scale (0 to 18). Median values, interquartile ranges, and individual values
See this image and copyright information in PMC

Comment in

References

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