Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003 Jan;111(1):19-21.
doi: 10.1172/JCI17506.

New weapons against inflammation: dual inhibitors of phospholipase A2 and transglutaminase

Lucio Miele  1
Affiliations
Review

New weapons against inflammation: dual inhibitors of phospholipase A2 and transglutaminase

Lucio Miele. J Clin Invest. 2003 Jan.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
sPLA2s hydrolyze the ester bond at the sn-2 position of membrane glycerophospholipids, generating free arachidonic acid. This acid is metabolized in a complex series of reactions involving COX or lipoxigenases (LOX), generating pro-inflammatory eicosanoids. TGase-catalyzed post-translational modifications activate sPLA2, potentially increasing eicosanoid production during acute inflammation. The new recombinant peptides contain a pro-elafin sequence that inhibits TGase and an antiflammin sequence that inhibits sPLA2. Thus they prevent TGase-induced sPLA2 activation.
See this image and copyright information in PMC

Comment on

References

    1. Murakami M, Kudo I. Phospholipase A2. J. Biochem. (Tokyo). 2002;131:285–292. - PubMed
    1. Barnes PJ. Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin. Sci. (Lond.). 1998;94:557–572. - PubMed
    1. Mukherjee, A.B., and Chilton, B.S. 2000. Uteroglobin/Clara cell family of proteins. New York Academy of Sciences. New York, New York, USA. 358 pp.
    1. Miele L, Cordella-Miele E, Facchiano A, Mukherjee AB. Novel anti-inflammatory peptides from the region of highest similarity between uteroglobin and lipocortin I. Nature. 1988;335:726–730. - PubMed
    1. Chowdhury B, et al. Lys 43 and Asp 46 in alpha-helix 3 of uteroglobin are essential for its phospholipase A2 inhibitory activity. Biochem. Biophys. Res. Commun. 2002;295:877–883. - PubMed