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Review
. 2003 Jan;111(1):25-7.
doi: 10.1172/JCI17564.

PARticipation in inflammation

Shaun R Coughlin  1 , Eric Camerer
Affiliations
Review

PARticipation in inflammation

Shaun R Coughlin et al. J Clin Invest. 2003 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Mechanism of PAR-1 activation. The N-terminus of PAR-1, a seven transmembrane domain G protein–coupled receptor, contains a protease cleavage site that, once cleaved by thrombin, results in a new N-terminus. The new N-terminal sequence, SFLLRN, acts as a tethered ligand and binds intramolecularly to the heptahelical body of the receptor to effect transmembrane signaling and G protein activation.
See this image and copyright information in PMC

Comment on

  • Essential role for proteinase-activated receptor-2 in arthritis.
    Ferrell WR, Lockhart JC, Kelso EB, Dunning L, Plevin R, Meek SE, Smith AJ, Hunter GD, McLean JS, McGarry F, Ramage R, Jiang L, Kanke T, Kawagoe J. Ferrell WR, et al. J Clin Invest. 2003 Jan;111(1):35-41. doi: 10.1172/JCI16913. J Clin Invest. 2003. PMID: 12511586 Free PMC article.

References

    1. Ferrell WR, et al. Essential role for proteinase activated receptor-2 in arthritis. J. Clin. Invest. 2003;111:35–41. doi:10.1172/JCI200316913. - PMC - PubMed
    1. Coughlin SR. Thrombin signaling and protease-activated receptors. Nature. 2000;407:258–264. - PubMed
    1. Vergnolle N, Wallace JL, Bunnett NW, Hollenberg MD. Protease-activated receptors in inflammation, neuronal signaling and pain. Trends. Pharmacol. Sci. 2001;22:146–152. - PubMed
    1. Fiorucci S, Distrutti E. Role of PAR2 in pain and inflammation. Trends. Pharmacol. Sci. 2002;23:153–155. - PubMed
    1. Weiss EJ, Hamilton JR, Lease KE, Coughlin SR. Protection against thrombosis in mice lacking PAR3. Blood. 2002;100:3240–3244. - PubMed