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. 1976 Feb 13;191(4227):569-71.
doi: 10.1126/science.1251192.

Proviral DNA of Moloney leukemia virus: purification and visualization

A M Gianni, J R Hutton, D Smotkin, R A Weinberg

Proviral DNA of Moloney leukemia virus: purification and visualization

A M Gianni et al. Science. .

Abstract

Closed-circular proviral DNA of Moloney leukemia virus has been purified from a 10(7) excess of cellular and mitochondrial DNA. The DNA can be visualized in the electron microscope and has the contour length of a molecule with a moleculecular weight of about 5.5 + 10(6). Electron microscopic observation of a hybrid between viral RNA and this circular DNA confirms the viral origin of this molecule.

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