[Approximate methods for calculation of the likelihood of radiation complications. The generalized PKLQ method (GPKLQM)]

Abstract

Search for rational schedules of radiation therapy for malignant tumors is a topical problem of modern radiology. It cannot be solved without prognostic estimates of radiation affecting tumor and normal organs and tissues. The aim of the study was to develop mathematical models to be used for approximate evaluation of radiation affecting a tumor focus and normal organs and tissues. This paper provides a theoretical rationale for the generalized PKLQ (GPKLQ) method for a random count of tumor tissue radio-resistant cells, which is based on the view of the effective count of radio-sensitive cells (the effective volume of a damage focus).