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. 2002 Jun;10(3):226-8.

[Immunophenotypic characteristics of multiple myeloma cells]

[Article in Chinese]
Jin-Lan Li  1 , Yan-Rong Liu, Yan Chang, Jia-Yu Fu, Shan-Shan Chen
Affiliations
  • PMID: 12513791

[Immunophenotypic characteristics of multiple myeloma cells]

[Article in Chinese]
Jin-Lan Li et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2002 Jun.

Abstract

To investigate the immunophenotypic characteristics of multiple myeloma (MM) cells, 20 bone marrow samples from patients with multiple myeloma were analyzed by flow cytometry with three-color direct immunofluorescence staining. Results showed that all of myeloma cells expressed bright CD38, dim or negative CD45 and negative CD19. Most of the cells were CD56(+) and a small portions were ckappa(+) or clambda(+), or CD20(+). The phenotypes of normal plasmocyte, CD19(+) and CD56(-), except CD56(-) in one-third samples, were not appeared in all detected samples. It was concluded that the surface marker analysis of myeloma cells is a useful tool for diagnosis and further evaluating prognosis of multiple myeloma.

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