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Clinical Trial
. 2003 Jan 4;361(9351):45-6.
doi: 10.1016/S0140-6736(03)12110-1.

Autologous bone-marrow stem-cell transplantation for myocardial regeneration

Christof Stamm  1 , Bernd Westphal, Hans-Dieter Kleine, Michael Petzsch, Christian Kittner, Heiko Klinge, Carl Schümichen, Christoph A Nienaber, Mathias Freund, Gustav Steinhoff
Affiliations
Clinical Trial

Autologous bone-marrow stem-cell transplantation for myocardial regeneration

Christof Stamm et al. Lancet. .

Abstract

Implantation of bone-marrow stem cells in the heart might be a new method to restore tissue viability after myocardial infarction. We injected up to 1.5x10(6) autologous AC133+ bone-marrow cells into the infarct border zone in six patients who had had a myocardial infarction and undergone coronary artery bypass grafting. 3-9 months after surgery, all patients were alive and well, global left-ventricular function was enhanced in four patients, and infarct tissue perfusion had improved strikingly in five patients. We believe that implantation of AC133+ stem cells to the heart is safe and might induce angiogenesis, thus improving perfusion of the infarcted myocardium. See Commentary page 11

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