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. 2003 Jan 1;31(1):307-10.
doi: 10.1093/nar/gkg085.

IMGT, the international ImMunoGeneTics database

Marie-Paule Lefranc  1
Affiliations

IMGT, the international ImMunoGeneTics database

Marie-Paule Lefranc. Nucleic Acids Res. .

Abstract

The international ImMunoGeneTics database (IMGT) (http://imgt.cines.fr), is a high quality integrated information system specializing in Immunoglobulins (IG), T cell Receptors (TR) and Major Histocompatibility Complex (MHC) of human and other vertebrates, created in 1989, by the Laboratoire d'ImmunoGénétique Moléculaire (LIGM), at the Université Montpellier II, CNRS, Montpellier, France. IMGT provides a common access to standardized data which include nucleotide and protein sequences, oligonucleotide primers, gene maps, genetic polymorphisms, specificities, 2D and 3D structures. IMGT includes three sequence databases (IMGT/LIGM-DB, IMGT/MHC-DB, IMGT/PRIMER-DB), one genome database (IMGT/GENE-DB) with different interfaces (IMGT/GeneSearch, IMGT/GeneView, IMGT/LocusView), one 3D structure database (IMGT/3Dstructure-DB), Web resources comprising 8000 HTML pages ('IMGT Marie-Paule page') and interactive tools for sequence analysis (IMGT/V-QUEST, IMGT/JunctionAnalysis, IMGT/Allele-Align, IMGT/PhyloGene). IMGT data are expertly annotated according to the rules of the IMGT Scientific chart, based on IMGT-ONTOLOGY. IMGT tools are particularly useful for the analysis of the IG and TR repertoires in physiological normal and pathological situations. IMGT has important applications in medical research (autoimmune diseases, AIDS, leukemias, lymphomas, myelomas), biotechnology related to antibody engineering (phage displays, combinatorial libraries) and thera-peutic approaches (graft, immunotherapy). IMGT is freely available at http://imgt.cines.fr.

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References

    1. Lefranc M.-P. and Lefranc,G. (2001) The Immunoglobulin FactsBook. Academic Press, London, UK, p. 458.
    1. Lefranc M.-P. and Lefranc,G. (2001) The T cell receptor FactsBook. Academic Press, London, UK, p. 398.
    1. Giudicelli V., Chaume,D., Bodmer,J., Müller,W., Busin,C., Marsh,S., Bontrop,R., Lemaitre,M., Malik,A. and Lefranc,M.-P. (1997) IMGT, the international ImMunoGeneTics database. Nucleic Acids Res., 25, 206–211. - PMC - PubMed
    1. Lefranc M.-P., Giudicelli,V., Busin,C., Bodmer,J., Müller,W., Bontrop,R., Lemaitre,M., Malik,A. and Chaume,D. (1998) IMGT, the international ImMunoGeneTics database. Nucleic Acids Res., 26, 297–303. - PMC - PubMed
    1. Lefranc M.-P., Giudicelli,V., Ginestoux,C., Bodmer,J., Müller,W., Bontrop,R., Lemaitre,M., Malik,A., Barbié,V. and Chaume,D. (1999) IMGT, the international ImMunoGeneTics database. Nucleic Acids Res., 27, 209–212. - PMC - PubMed

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