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. 2003 Jan 1;31(1):315-8.
doi: 10.1093/nar/gkg046.

The InterPro Database, 2003 brings increased coverage and new features

Nicola J Mulder  1 , Rolf Apweiler, Teresa K Attwood, Amos Bairoch, Daniel Barrell, Alex Bateman, David Binns, Margaret Biswas, Paul Bradley, Peer Bork, Phillip Bucher, Richard R Copley, Emmanuel Courcelle, Ujjwal Das, Richard Durbin, Laurent Falquet, Wolfgang Fleischmann, Sam Griffiths-Jones, Daniel Haft, Nicola Harte, Nicolas Hulo, Daniel Kahn, Alexander Kanapin, Maria Krestyaninova, Rodrigo Lopez, Ivica Letunic, David Lonsdale, Ville Silventoinen, Sandra E Orchard, Marco Pagni, David Peyruc, Chris P Ponting, Jeremy D Selengut, Florence Servant, Christian J A Sigrist, Robert Vaughan, Evgueni M Zdobnov
Affiliations

The InterPro Database, 2003 brings increased coverage and new features

Nicola J Mulder et al. Nucleic Acids Res. .

Abstract

InterPro, an integrated documentation resource of protein families, domains and functional sites, was created in 1999 as a means of amalgamating the major protein signature databases into one comprehensive resource. PROSITE, Pfam, PRINTS, ProDom, SMART and TIGRFAMs have been manually integrated and curated and are available in InterPro for text- and sequence-based searching. The results are provided in a single format that rationalises the results that would be obtained by searching the member databases individually. The latest release of InterPro contains 5629 entries describing 4280 families, 1239 domains, 95 repeats and 15 post-translational modifications. Currently, the combined signatures in InterPro cover more than 74% of all proteins in SWISS-PROT and TrEMBL, an increase of nearly 15% since the inception of InterPro. New features of the database include improved searching capabilities and enhanced graphical user interfaces for visualisation of the data. The database is available via a webserver (http://www.ebi.ac.uk/interpro) and anonymous FTP (ftp://ftp.ebi.ac.uk/pub/databases/interpro).

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Figures

Figure 1
Figure 1
New graphical user interface for viewing protein matches of a particular InterPro entry. (A) Graphical view of representative list of proteins matching IPR000340, in which consensus domain boundaries have been computed for the domain line, and parent and children entries have been collapsed into one family line. This enables the family and domain composition information to be seen at a glance. (B) From the “more proteins in list” link in view a.) it is possible to show all proteins sharing a common domain architecture These protein sequences can then be retrieved or their alignments can be visualised.
Figure 1
Figure 1
New graphical user interface for viewing protein matches of a particular InterPro entry. (A) Graphical view of representative list of proteins matching IPR000340, in which consensus domain boundaries have been computed for the domain line, and parent and children entries have been collapsed into one family line. This enables the family and domain composition information to be seen at a glance. (B) From the “more proteins in list” link in view a.) it is possible to show all proteins sharing a common domain architecture These protein sequences can then be retrieved or their alignments can be visualised.
See this image and copyright information in PMC

References

    1. Falquet L., Pagni,M., Bucher,P., Hulo,N., Sigrist,C.J.A., Hofmann,K. and Bairoch,A. (2002) The PROSITE database, its status in 2002. Nucleic Acids Res., 30, 235–238. - PMC - PubMed
    1. Attwood T.K., Blythe,M.J., Flower,D.R., Gaulton,A., Mabey,J.E., Maudling,N., McGregor,L., Mitchell,A.L., Moulton,G., Paine,K. et al. (2002) PRINTS and PRINTS-S shed light on protein ancestry. Nucleic Acids Res., 30, 239–241. - PMC - PubMed
    1. Bateman A., Birney,E., Cerruti,L., Durbin,R., Etwiller,L., Eddy,S.R., Griffiths-Jones,S., Howe,K.L., Marshall,M. and Sonnhammer,E.L.L. (2002) The Pfam Protein Families Database. Nucleic Acids Res., 30, 276–280. - PMC - PubMed
    1. Corpet F., Servant,F., Gouzy,J. and Kahn,D. (2000) ProDom and ProDom-CG: tools for protein domain analysis and whole genome comparisons. Nucleic Acids Res., 28, 267–269. - PMC - PubMed
    1. Apweiler R., Attwood,T.K., Bairoch,A., Bateman,A., Birney,E., Biswas,M., Bucher,P., Cerutti,L., Corpet,F., Croning,M.D. et al. (2001) The InterPro database, an integrated documentation resource for protein families, domains and functional sites. Nucleic Acids Res., 29, 37–40. - PMC - PubMed

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