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Clinical Trial
. 1976 Mar;94(3):273-5.
doi: 10.1111/j.1365-2133.1976.tb04383.x.

Prostaglandins and pruritus

C R Lovell, P A Burton, E H Duncan, J L Burton
Clinical Trial

Prostaglandins and pruritus

C R Lovell et al. Br J Dermatol. 1976 Mar.

Abstract

We have found that pretreatment of human skin with prostaglandin E1 significantly lowers the threshold of human skin to itching evoked by both histamine and papain. Prostaglandins may thus potentiate pruritus in inflammatory skin disease, presumably by a non-specific effect on nerve-endings.

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