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Review
. 2003 Jan 9;37(1):7-10.
doi: 10.1016/s0896-6273(02)01166-2.

Pathways to Parkinsonism

Mark R Cookson  1
Affiliations
Free article
Review

Pathways to Parkinsonism

Mark R Cookson. Neuron. .
Free article

Abstract

A novel gene for Parkinson's disease (PD), DJ-1, has been identified that encodes a multifunctional product with several known protein-protein interactions and effects on gene expression. Here, I outline how it is possible to construct hypotheses that place DJ-1 in different relationships to the other known PD genes, alpha-synuclein and parkin. The identification of multiple genetic causes will provide further impetus to describe the pathway leading to PD.

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