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Review
. 2003 Jan 15;31(2):517-31.
doi: 10.1093/nar/gkg137.

Mutagenic potentials of damaged nucleic acids produced by reactive oxygen/nitrogen species: approaches using synthetic oligonucleotides and nucleotides: survey and summary

Hiroyuki Kamiya  1
Affiliations
Review

Mutagenic potentials of damaged nucleic acids produced by reactive oxygen/nitrogen species: approaches using synthetic oligonucleotides and nucleotides: survey and summary

Hiroyuki Kamiya. Nucleic Acids Res. .

Abstract

DNA and DNA precursors (deoxyribonucleotides) suffer damage by reactive oxygen/nitrogen species. They are important mutagens for organisms, due to their endogenous formation. Damaged DNA and nucleotides cause alterations of the genetic information by the mispairing properties of the damaged bases, such as 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) and 2-hydroxyadenine. Here, the author reviews the mutagenic potentials of damaged bases in DNA and of damaged DNA precursors formed by reactive oxygen/nitrogen species, focusing on the results obtained with synthetic oligonucleotides and 2'-deoxyribonucleoside 5'-triphosphates.

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Figures

Figure 1
Figure 1
Structures of DNA lesions described in this paper. (A) Damaged bases produced by ROS/RNS. Only the base moiety is shown. Oxanine is the base for deoxyoxanosine 5′-triphosphate. (B) A true abasic site and its analog.
Figure 2
Figure 2
Hydrogen-bonding patterns of (A) 8-OH-Gua·C and 8-OH-Gua·A pairs, (B) 8-OH-Ade·T and 8-OH-Ade·G pairs, (C) Hyp·C and Hyp·A pairs and (D) 5-CHO-Ura·A and 5-CHO-Ura·G pairs.
See this image and copyright information in PMC

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