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Case Reports
. 2002 Dec;63(6 Pt 1):536-9.

[Acromegaly due to ectopic GH RH secretion by a bronchial carcinoid tumor: a case report]

[Article in French]
Y Lorcy  1 , S Perdu, B Sevray, R Cohen
Affiliations
  • PMID: 12527856
Case Reports

[Acromegaly due to ectopic GH RH secretion by a bronchial carcinoid tumor: a case report]

[Article in French]
Y Lorcy et al. Ann Endocrinol (Paris). 2002 Dec.

Abstract

Ectopic GH RH is a very uncommon cause of acromegaly (<1% of acromegaly). We report the case of an 41 year-old woman with acromegaly due to a GH-RH-secreting bronchial carcinoid tumor. Elevated serum GH (14 ng/ml) was paradoxically stimulated after glucose loading. Magnetic resonance imaging revealed a normal pituitary gland. The thoracic CT demonstrated a voluminous (8 cm) bronchial tumor visualised with octreotide scintigraphy. Acromegaly due to ectopic GH RH secretion was confirmed by very high plasma immunoreactive GH RH level. After removal of the carcinoid tumor, plasmat GH, IGF1 and GH RH levels were normalised.

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