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. 1976 Jan 24;114(2):140-1, 145.

Disseminated histoplasmosis and necrotizing vasculitis

P Small, P Levitt

Disseminated histoplasmosis and necrotizing vasculitis

P Small et al. Can Med Assoc J. .

Abstract

A 74-year-old man with congestive heart failure was found to have Histoplasma capsulatum in a lesion of the right nasal septum. His initial treatment with amphotericin B was inadequate because of severe intolerance to the drug. Three months after initial presentation H. capsulatum was detected in his blood and bone marrow. Slightly elevated purpuric lesions on the arms, lower legs and trunk showed the typical features of necrotizing vasculitis. Cutaneous anergy was reversed after treatment with transfer factor. Skin involvement in disseminated histoplasmosis is unusual and there are no previous reports of vasculitis associated with this infection.

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