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Review
. 2003 Jan 30;21(7-8):667-70.
doi: 10.1016/s0264-410x(02)00577-7.

Mycobacterium bovis BCG-based vaccines against tuberculosis: novel developments

Guido Dietrich  1 , Jean-Francois Viret, Jürgen Hess
Affiliations
Review

Mycobacterium bovis BCG-based vaccines against tuberculosis: novel developments

Guido Dietrich et al. Vaccine. .

Abstract

Mycobacterium bovis Bacille Calmette-Guérin (BCG) is one of the most widely used vaccines. Modern techniques in genome manipulation allow the construction of recombinant (r)-BCG strains that can be employed as highly immunogenic vaccines against tuberculosis (TB) with an enhanced safety profile. In addition, the development of novel procedures to cultivate BCG will allow the large-scale production of future BCG-based vaccines.

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