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. 2003 Jan;111(2):171-2.
doi: 10.1172/JCI17597.

A role for nitric oxide in hydroxyurea-mediated fetal hemoglobin induction

S Bruce King  1
Affiliations

A role for nitric oxide in hydroxyurea-mediated fetal hemoglobin induction

S Bruce King. J Clin Invest. 2003 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Mechanism of fetal hemoglobin induction by hydroxyurea. Hydroxyurea is metabolized by an unknown pathway to produce nitric oxide that binds and activates sGC. Alternatively, hydroxyurea may be able to directly activate sGC. Activation of sGC increases production of cGMP, which probably influences some transcription factors leading to increased fetal hemoglobin synthesis.
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References

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