Disseminated granulocytic sarcoma treated with allogeneic peripheral blood stem-cell transplantation

Abstract

Primary granulocytic sarcoma is a rare disorder that presents as an extramedullary myeloid cell tumour. In this case, we describe a 35-year-old woman who developed widely disseminated granulocytic sarcomas three months after she received local radiotherapy to a primary granulocytic sarcoma of the cervical spine. These disseminated sarcomas initially responded to combination chemotherapy but this approach was only partly successful as the woman was left with increasing residual disease in the mediastinum. She was then treated with an allogeneic peripheral blood stem-cell transplant that led to complete resolution of her disease. This case demonstrates the effectiveness of allogeneic stem-cell transplantation in the treatment of progressive granulocytic sarcoma present after high-dose chemotherapy.