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. 1976 Mar-Apr:(115):286-90.

An ultrastructural evaluation of the effect of hydrocortisone on rabbit cartilage

W D Barker, J Martinek
  • PMID: 1253492

An ultrastructural evaluation of the effect of hydrocortisone on rabbit cartilage

W D Barker et al. Clin Orthop Relat Res. 1976 Mar-Apr.

Abstract

Pharmacologic and supra-pharmacologic doses of hydrocortisone acetate did not effect ultrastructural alteration of chondrocytes in articular cartilage of mature rabbits. Early biomechanical alterations are unaccompanied by ultrastructural cytological changes. Not until advanced biochemical alteration is effected by large, repetitive doses, does the ultrastructural alteration begin.

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