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. 1976 Jan;35(1):121-5.
doi: 10.1016/0014-2999(76)90306-x.

Photoaffinity labeling of the beta-adrenergic receptors and receptor reserve for isoprenaline

I Takayanagi, M Yoshioka, K Takagu, Z Tamura

Photoaffinity labeling of the beta-adrenergic receptors and receptor reserve for isoprenaline

I Takayanagi et al. Eur J Pharmacol. 1976 Jan.

Abstract

The beta-adrenergic receptors in the taenia isolated from the guinea pig caecum were irreversibly inactivated by photoaffinity labeling with 1-isoprenaline and 2-(2-hydroxy-3-isopropylaminopropoxy)iodobenzene. The photoinactivation was eliminated in the presence of protectors of the receptors. Photoinactivation caused a considerable parallel shift in the concentration-action curve of 1-isoprenaline. The results possibly point to a certain receptor reserve for 1-isoprenaline.

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