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. 2003 Feb;4(2):161-7.
doi: 10.1038/ni886. Epub 2003 Jan 21.

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

Hiroyuki Oshiumi  1 , Misako Matsumoto, Kenji Funami, Takashi Akazawa, Tsukasa Seya
Affiliations

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

Hiroyuki Oshiumi et al. Nat Immunol. 2003 Feb.

Abstract

Human Toll-like receptor (TLR) 3 recognizes double-stranded (ds) RNA and induces production of interferon (IFN)-beta independent of the adaptor molecules MyD88 and TIRAP. Thus, another adaptor must exist that preferentially mediates TLR3-dependent production of IFN-beta. We have identified an alternative adaptor, designated Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule (TICAM)-1, that can physically bind the TIR domain of TLR3 and activate the IFN-beta promoter in response to poly(I):poly(C). Thus, dsRNA-TLR3-dependent production of IFN-beta is mediated mainly by TICAM-1. This TICAM-1-dependent pathway may have a role in other TLR-IFN-beta pathways, which form part of the MyD88-independent cellular immune response.

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