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. 2003 Jan;66(1):140-2.
doi: 10.1021/np0203537.

A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris)

Giovanni Appendino  1 , Carla Della Porta, Gwenaëlle Conseil, Olov Sterner, Enrico Mercalli, Charles Dumontet, Attilio Di Pietro
Affiliations

A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris)

Giovanni Appendino et al. J Nat Prod. 2003 Jan.

Abstract

The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.

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