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Comparative Study
. 2003 Feb;74(3):691-9.
doi: 10.1016/s0091-3057(02)01069-9.

The effect of electroacupuncture as an adjunct on cyclophosphamide-induced emesis in ferrets

Lixing Lao  1 , Grant Zhang, Richard H Wong, Aaron K Carter, Richard L Wynn, Brian M Berman
Affiliations
Comparative Study

The effect of electroacupuncture as an adjunct on cyclophosphamide-induced emesis in ferrets

Lixing Lao et al. Pharmacol Biochem Behav. 2003 Feb.

Abstract

The effect of electroacupuncture (EA) on cyclophosphamide-induced emesis in ferrets was studied at acupuncture point Neiguan (P6) with various electrical stimulation parameters (5-100 Hz, 1.5-3 V, 5-20 min, n=6/group). The combination therapy of EA (100 Hz, 1.5 V and 10 min) with the lower doses of ondansetron (0.04 mg/kg), droperidol (0.25 mg/kg) and metoclopramide (2.24 mg/kg) significantly reduced the total number of emetic episodes by 52%, 36% and 73%, respectively, as well as the number of emetic episodes in the first phase as compared to the sham acupuncture control (P<.01). These EA/drug combinations also showed a significant effect in preventing emesis as compared to either EA or drug alone (P<.05). The present study suggests that acupuncture may be useful as an adjunctive therapy in the treatment of chemotherapy-induced emesis.

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