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Clinical Trial
. 2003 Feb;87(2):147-8.
doi: 10.1136/bjo.87.2.147.

Community treatment with azithromycin for trachoma is not associated with antibiotic resistance in Streptococcus pneumoniae at 1 year

B D Gaynor  1 , K A Holbrook, J P Whitcher, S O Holm, H C Jha, J S P Chaudhary, R C Bhatta, T Lietman
Affiliations
Clinical Trial

Community treatment with azithromycin for trachoma is not associated with antibiotic resistance in Streptococcus pneumoniae at 1 year

B D Gaynor et al. Br J Ophthalmol. 2003 Feb.

Abstract

Aims: To determine if macrolide resistant Streptococcus pneumoniae will be a major concern in areas that receive annual mass azithromycin distributions for trachoma.

Methods: A cross sectional survey was conducted of nasopharyngeal S pneumoniae isolates for susceptibility to azithromycin 1 year after administering a single dose of azithromycin to treat trachoma in a village in Nepal.

Results: S pneumoniae was isolated from 50 (86%) of 57 nasopharyngeal cultures and no resistance to azithromycin was detected.

Conclusion: The authors were unable to demonstrate that mass azithromycin therapy for trachoma produced macrolide resistant S pneumoniae that persists until the next scheduled annual treatment.

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References

    1. Schachter J, West SK, Mabey D, et al. Azithromycin in control of trachoma. Lancet 1999;354:630–5. - PubMed
    1. Laming AC, Currie BJ, DiFrancesco M, et al. A targeted, single-dose azithromycin strategy for trachoma. Med J Aust 2000;172:163–6. - PubMed
    1. Bailey RL, Arullendran P, Whittle HC, et al. Randomised controlled trial of single-dose azithromycin in treatment of trachoma. Lancet 1993;342:453–6. - PubMed
    1. Dawson CR, Schachter J, Sallam S, et al. A comparison of oral azithromycin with topical oxytetracycline/polymyxin for the treatment of trachoma in children. Clin Infect Dis 1997;24:363–8. - PubMed
    1. Tabbara KF, Abu-el-Asrar A, al-Omar O, et al. Single-dose azithromycin in the treatment of trachoma. A randomized, controlled study. Ophthalmology 1996;103:842–6. - PubMed

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