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Clinical Trial
. 2003 Feb;87(2):189-96.
doi: 10.1136/bjo.87.2.189.

Optic disc morphology in south India: the Vellore Eye Study

J B Jonas  1 , R Thomas, R George, E Berenshtein, J Muliyil
Affiliations
Clinical Trial

Optic disc morphology in south India: the Vellore Eye Study

J B Jonas et al. Br J Ophthalmol. 2003 Feb.

Abstract

Aim: To evaluate the morphology of the optic nerve head in an unselected population group in south India.

Methods: The study included 70 subjects forming a population based sample, selected in a random manner. Mean age was 47.5 (SD 8.7) years, mean refractive error measured -0.07 (1.11) dioptres (range -4.50 to +2.50 dioptres). Optic disc slides were morphometrically analysed.

Results: Mean optic disc area measured 2.58 (0.65) mm(2). It was statistically independent of age and refractive error. Optic disc shape was slightly vertically oval. Mean neuroretinal rim area was 1.60 (0.37) mm(2). It was significantly and positively correlated with optic disc size and optic cup size. It was independent of age, sex, refractive error, and axial length. In all subjects included in the study, the rim was smallest in the temporal horizontal optic disc sector. Mean horizontal cup/disc diameter ratio (0.66 (0.07)) was significantly (p<0.001) higher than the mean vertical cup/disc diameter ratio (0.56 (0.08)). Both ratios were highly significantly (p <0.001) and positively correlated with optic disc size. The alpha zone of parapapillary atrophy (0.84 (0.29) mm(2)), and beta zone (0.13 (0.38) mm(2)), respectively, occurred in 69 (98.6%) subjects and in eight (11.4%) subjects, respectively. They were significantly larger in the temporal horizontal sector. The alpha zone was significantly (p<0.001) larger and occurred significantly more often than beta zone. Retinal arterioles and venules were wider, and in spatial correlation, the visibility of the retinal nerve fibre layer was significantly better, in the temporal inferior disc arcade and the temporal superior arcade than in the nasal superior arcade and the nasal inferior vessel arcade. Except for the absolute size measurements these optic nerve head parameters did not differ markedly (p >0.05) from the values found in white people.

Conclusions: South Indians and white people do not show marked differences in the morphology of the optic nerve head as measured by morphometric optic disc parameters, with the possible exception of the absolute optic disc dimensions.

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Figures

Figure 1
Figure 1
Histogram showing the distribution of optic disc area in a randomly selected sample of 70 subjects from Vellore, Tamil Nadu.
Figure 2
Figure 2
Histogram showing the distribution of horizontal optic disc diameter in a randomly selected sample of 70 subjects from Vellore, Tamil Nadu.
Figure 3
Figure 3
Histogram showing the distribution of neuroretinal rim area in a randomly selected sample of 70 subjects from Vellore, Tamil Nadu.
Figure 4
Figure 4
Histogram showing the correlation between neuroretinal rim area and optic disc area in a randomly selected sample of 70 subjects from Vellore, Tamil Nadu. (Correlation coefficient r = 0.85; equation of the regression line: neuroretinal rim area (mm2) = 0.48 × optic disc area (mm2) + 0.37; p <0.001.)
Figure 5
Figure 5
Scattergram showing the correlation between optic cup area and optic disc area in a randomly selected sample of 70 subjects from Vellore, Tamil Nadu. (Correlation coefficient r = 0.87; equation of the regression line: optic cup area (mm2) = 0.52 × optic disc area (mm2) − 0.37; p <0.001.)
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References

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