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. 2003 Jan 15;63(2):296-7.

Insulin-like growth factor II receptor gene-167 genotype increases the risk of oral squamous cell carcinoma in humans

Athanasios I Zavras  1 , Waranuch Pitiphat, Tianxia Wu, Vassiliki Cartsos, Albert Lam, Chester W Douglass, Scott R Diehl
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  • PMID: 12543777

Insulin-like growth factor II receptor gene-167 genotype increases the risk of oral squamous cell carcinoma in humans

Athanasios I Zavras et al. Cancer Res. .

Abstract

Our purpose was to evaluate inherited short tandem repeat polymorphisms of the insulin-like growth factor II receptor gene (IGF2R) in oral cancer risk. The 197 individuals that consented to participate in a hospital-based, case-control study were interviewed with a structured questionnaire and provided blood and saliva. DNA was extracted for genotyping using a PCR-based method. Odds ratios were calculated using multivariate logistic regression. Subjects carrying the heterozygous 167-bp IGF2R genotype had a 2.7-fold higher risk of oral cancer compared with subjects with other genotypes (odds ratio = 2.7, 95% confidence interval: 1.16-6.48), controlling for major confounders. Our results suggest that genetic variation of IGF2R may influence significantly the risk of oral cancer.

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