Review
doi: 10.1146/annurev.immunol.21.120601.141057.
Epub 2001 Dec 19.
The regulatory role of Valpha14 NKT cells in innate and acquired immune response
Affiliations
- PMID: 12543936
- DOI: 10.1146/annurev.immunol.21.120601.141057
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Review
The regulatory role of Valpha14 NKT cells in innate and acquired immune response
Annu Rev Immunol.
2003.
Abstract
A novel lymphocyte lineage, Valpha14 natural killer T (NKT) cells, is now well established as distinct from conventional alphabeta T cells. Valpha14 NKT cells express a single invariant Valpha14 antigen receptor that is essential for their development. Successful identification of a specific ligand, alpha-galactosylceramide(alpha-GalCer), and the establishment of gene-manipulated mice with selective loss of Valpha14 NKT cells helped elucidate the remarkable functional diversity of Valpha14 NKT cells in various immune responses such as host defense by mediating anti-nonself innate immune reaction, homeostatic regulation of anti-self responses, and antitumor immunity.
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