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Review
. 2003:21:483-513.
doi: 10.1146/annurev.immunol.21.120601.141057. Epub 2001 Dec 19.

The regulatory role of Valpha14 NKT cells in innate and acquired immune response

Masaru Taniguchi  1 , Michishige Harada, Satoshi Kojo, Toshinori Nakayama, Hiroshi Wakao
Affiliations
Review

The regulatory role of Valpha14 NKT cells in innate and acquired immune response

Masaru Taniguchi et al. Annu Rev Immunol. 2003.

Abstract

A novel lymphocyte lineage, Valpha14 natural killer T (NKT) cells, is now well established as distinct from conventional alphabeta T cells. Valpha14 NKT cells express a single invariant Valpha14 antigen receptor that is essential for their development. Successful identification of a specific ligand, alpha-galactosylceramide(alpha-GalCer), and the establishment of gene-manipulated mice with selective loss of Valpha14 NKT cells helped elucidate the remarkable functional diversity of Valpha14 NKT cells in various immune responses such as host defense by mediating anti-nonself innate immune reaction, homeostatic regulation of anti-self responses, and antitumor immunity.

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