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Review
. 2003 Feb;14(1):21-7.
doi: 10.1097/00041433-200302000-00005.

Effects of phenolics on vascular endothelial function

Affiliations
Review

Effects of phenolics on vascular endothelial function

Stephen J Duffy et al. Curr Opin Lipidol. 2003 Feb.

Abstract

Purpose of review: There continues to be considerable interest in the concept that antioxidant therapy may reduce cardiovascular risk. Phenols have antioxidant properties and may be important micronutrients. Epidemiological studies have demonstrated a strong link between phenolic intake and reduced cardiovascular risk, but the mechanism of benefit has not been determined.

Recent findings: Recent evidence has emerged that a number of phenolic compounds, particularly flavonoids, reverse vascular endothelial dysfunction. The normal endothelium plays a critical role in regulating vascular function, and endothelial dysfunction is associated with increased cardiovascular risk. The present article reviews the links between phenolic intake, endothelial function and cardiovascular risk.

Summary: Endothelium-derived nitric oxide bioactivity appears to be increased by supplementation with a number of phenols, and this may explain some of the favourable effects of high phenolic intake seen in epidemiological studies.

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