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Review
. 2002;50(6):371-8.

Predicting outcome in hematological stem cell transplantation

Anne M Dickinson  1 , James Cavet, Hannah Cullup, Xiao N Wang, Mark Jarvis, Lisbet Sviland, Peter G Middleton
Affiliations
  • PMID: 12546063
Review

Predicting outcome in hematological stem cell transplantation

Anne M Dickinson et al. Arch Immunol Ther Exp (Warsz). 2002.

Abstract

This review summarizes recent results investigating the role of certain cytokine gene polymorphisms, including those of TNF-alpha, IFN-gamma, IL-6, IL-10 and IL-1 receptor antagonist (IL-1Ra), in allogeneic stem cell transplantation. It discusses their role in predicting outcome and the development of a genetic risk index for graft versus host disease (GvHD) in HLA-matched sibling transplants. By the comparative use of an in vitro human skin explant model, initial results suggest that certain cytokine gene polymorphisms may be associated with more severe disease.

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