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Review

. 2002 Nov-Dec;1(6):401-3.

doi: 10.4161/cc.1.6.264.

CHK2: a tumor suppressor or not?

Clare H McGowan¹

Affiliations

PMID: 12548013
DOI: 10.4161/cc.1.6.264

Review

CHK2: a tumor suppressor or not?

Clare H McGowan. Cell Cycle. 2002 Nov-Dec.

. 2002 Nov-Dec;1(6):401-3.

doi: 10.4161/cc.1.6.264.

Author

Clare H McGowan¹

Affiliation

¹ Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA. chmcg@scripps.edu

PMID: 12548013
DOI: 10.4161/cc.1.6.264

No abstract available

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Comment on

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, Elledge SJ, Mak TW. Hirao A, et al. Mol Cell Biol. 2002 Sep;22(18):6521-32. doi: 10.1128/MCB.22.18.6521-6532.2002. Mol Cell Biol. 2002. PMID: 12192050 Free PMC article.
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription.
Takai H, Naka K, Okada Y, Watanabe M, Harada N, Saito S, Anderson CW, Appella E, Nakanishi M, Suzuki H, Nagashima K, Sawa H, Ikeda K, Motoyama N. Takai H, et al. EMBO J. 2002 Oct 1;21(19):5195-205. doi: 10.1093/emboj/cdf506. EMBO J. 2002. PMID: 12356735 Free PMC article.

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