Standardized mistletoe extract augments immune response and down-regulates local and metastatic tumor growth in murine models
- PMID: 12553054
Standardized mistletoe extract augments immune response and down-regulates local and metastatic tumor growth in murine models
Abstract
The immunomodulatory and antimetastatic activity of standardized aqueous mistletoe extract (sME) was evaluated in BALB/c-mice. Regular subcutaneous (s.c.) applications (three times per week for 14 consecutive days; 2, 20, 100 and 500 micrograms per injection and mouse) up-regulated thymocyte and peripheral blood leukocyte counts in tumor-bearing mice. Tumor weight and tumor volume were significantly down-regulated after application of sME doses greater than 20 micrograms per injection. To check the influence of sME treatment on growth of experimental metastases, RAW 117 H 10 lymphosarcoma cells and L-1 sarcoma cells were intravenously inoculated into BALB/c-mice to establish liver and lung colonization, respectively. sME was regularly administered starting 24 hours after tumor cell challenge. Organ colonization was investigated on day 14 after tumor cell inoculation and demonstrated statistically significant (p < 0.05) reductions of experimental liver and lung metastases for sME-treated mice.
Similar articles
-
Anticancer activity of rViscumin (recombinant mistletoe lectin) in tumor colonization models with immunocompetent mice.Anticancer Res. 2001 Nov-Dec;21(6A):3981-7. Anticancer Res. 2001. PMID: 11911280
-
Application-dependent immunomodulating and antimetastatic efficacy of thymic peptides in BALB/c-mice.In Vivo. 2001 Sep-Oct;15(5):403-6. In Vivo. 2001. PMID: 11695237
-
Thymic humoral factor-gamma 2 augments immune cell response and exerts antitumor activity in murine model systems.Anticancer Res. 2000 Nov-Dec;20(6B):4473-6. Anticancer Res. 2000. PMID: 11205290
-
From ill-defined extracts to the immunomodulatory lectin: will there be a reason for oncological application of mistletoe?Planta Med. 1994 Feb;60(1):2-7. doi: 10.1055/s-2006-959396. Planta Med. 1994. PMID: 8134410 Review.
-
Mistletoe extracts standardized to mistletoe lectins in oncology: review on current status of preclinical research.Anticancer Res. 2002 May-Jun;22(3):1399-407. Anticancer Res. 2002. PMID: 12168816 Review.
Cited by
-
[Influence of ML-1 standardized mistletoe extract on the quality of life in head and neck cancer patients].HNO. 2006 Apr;54(4):277-86. doi: 10.1007/s00106-005-1318-y. HNO. 2006. PMID: 16132877 Clinical Trial. German.
-
Multiple Active Compounds from Viscum album L. Synergistically Converge to Promote Apoptosis in Ewing Sarcoma.PLoS One. 2016 Sep 2;11(9):e0159749. doi: 10.1371/journal.pone.0159749. eCollection 2016. PLoS One. 2016. PMID: 27589063 Free PMC article.
-
A Randomized Study on Postrelapse Disease-Free Survival with Adjuvant Mistletoe versus Oral Etoposide in Osteosarcoma Patients.Evid Based Complement Alternat Med. 2014;2014:210198. doi: 10.1155/2014/210198. Epub 2014 Mar 31. Evid Based Complement Alternat Med. 2014. PMID: 24803944 Free PMC article.
-
Differential Effects of Viscum album Preparations on the Maturation and Activation of Human Dendritic Cells and CD4⁺ T Cell Responses.Molecules. 2016 Jul 14;21(7):912. doi: 10.3390/molecules21070912. Molecules. 2016. PMID: 27428940 Free PMC article.
-
Viscum album (L.) in experimental animal tumors: A meta-analysis.Exp Ther Med. 2017 Jun;13(6):2723-2740. doi: 10.3892/etm.2017.4372. Epub 2017 Apr 21. Exp Ther Med. 2017. PMID: 28596809 Free PMC article.