doi: 10.1021/ja0283201.
Catalytic asymmetric silane alcoholysis: practical access to chiral silanes
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- PMID: 12553820
- DOI: 10.1021/ja0283201
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Catalytic asymmetric silane alcoholysis: practical access to chiral silanes
J Am Chem Soc.
.
Abstract
A new asymmetric synthesis of chiral silanes has been developed. Chiral phosphine-modified copper complexes catalyze the alcoholysis of prochiral dihydrosilanes with good to excellent stereoselectivity at silicon. The application of this methodology to the tandem silylformylation-allylsilylation of alkynes has been demonstrated.
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