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. 2003 Feb 5;125(5):1190-1.
doi: 10.1021/ja0283201.

Catalytic asymmetric silane alcoholysis: practical access to chiral silanes

Darby R Schmidt  1 , Steven J O'Malley, James L Leighton
Affiliations

Catalytic asymmetric silane alcoholysis: practical access to chiral silanes

Darby R Schmidt et al. J Am Chem Soc. .

Abstract

A new asymmetric synthesis of chiral silanes has been developed. Chiral phosphine-modified copper complexes catalyze the alcoholysis of prochiral dihydrosilanes with good to excellent stereoselectivity at silicon. The application of this methodology to the tandem silylformylation-allylsilylation of alkynes has been demonstrated.

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